Campo Marine Moisturising Factor 1 is a total isolate form of Corallina officinalis alba (Coral Seaweed). It is tissue cultured and propagated in biotechnology vats in a controlled laboratory environment. this total extract isolate affords a number of substances resembling the water soluble natural moisturising factors (NMF) of the horny layer of human skin.

Propagation of this unique species of coral algae occurs from fragments which are broken off by wave action. It is believed that these moisturising factors participate in, or facilitate, thepropagation of new individuals of the algae.

The highest content of NMF-like substances is afforded by these fragments (which are already in the process of developing into fully fledged individuals) when they are washed on to the shore and marooned on the beach during the ebb tide. It has been noted that these fragments afford the optimum concentrations of NMF-like substances.

This is believed to be due to the action of the strong Pacific sun on the broken propagating fragments which are being subjected to UV and IR radiation and heat induced dehydration. Other factors such as harsh chemical reactions may also trigger a similar response, similar to the action of soap and other anionic detergents on human skin.

A high throughput screening (HTS of the total extract, as part of a tertiary screening programme to find new AI’s, revealed a number of new bio-active compounds, in addition to other more common compounds such as amino acids, urea, fructose, niacinamide, cinnamic acid esters,etc..

graph 1

The most interesting of the many novel new bio-active engineered compounds are thoseanalogues having a structural resemblance to compounds already of interest to the cosmeticsformulator:

- COMPOUNDS IDENTIFIED IN CAMPO MMF1

*		2-pyrrolidone-5-carboxylic acid in various salt forms including the sodium salt ( Sodium PCA, as listed in CTFA Cosmetic Ingredient Dictionary, 3rd ed., 1982, p268.)
*		lactates in three salt forms including the sodium salt ( sodium lactate listed in CTFA Cosmetic Ingredient Dictionary, 3rd ed., p283, and DAB, p331 )
*		12-epi-scalaradial - like analogue. It is known that 12-epi-scalaradial, a marine natural product, previously known only and isolated from cacospongia spp., is a potent inhibitor of bee sting and other venoms.
*		spermidine
*		spermine
*		6-methoxy-N- (3-sulphopropyl)- quinoline (SPQ)

- KNOWN PHYSIOLOGICAL EFFECTS OF ISOLATED COMPOUNDS

It is interesting to note that the lactate and PCA in the form of their sodium salts are well known for water bridging properties, and are widely used in cosmetics formulations for this moisturisingeffect.

12-epi-scalaradial acts as a potent inhibitor of toxins.

Spermine and spermidine are polyamines with the biological function of protection of replicating DNA against oxidative injury. Their intercellular concentration is strictly correlated to normaland pathological cell growth and protein synthesis. Spermine plays an important role in the regulation of cellular proliferation and differentiation, whilst it also facilitates regeneration of long term potentiation and protects replicating DNA against damage by singlet oxygen.

SPQ has an inferred bioloogical function of minimising interference of physiological anions ( and anionic detergents).

Snow White Coral Algae products :
new drug discovery | specifications | s-white coral algae | table-1 | efficiency of broadspectrum | corallina offincinalis alba | table-2 | tech-specification | formula guide | microbiological data sheet | final report | assay |

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