What is Hydrin I and II ( ex-Songyi mushroom isolate ) ?

Corium layer of the human skin (i.e. the demis ) contains collagen which is the principal protein constituent of the connective tissues, skin, tendon and bone. The corium layer, for example consists of 90 to 95% collagen, on dry basis; and the important pre-cursors and their functional catalysis for the water-electrolyte regulation, water-balance activity and hydro-osmotic activity are peptides - amino acid residues cross-linked to vasotocin are known as hydrins - a sub-micro-molecule.

Hydrins are also known to exists in other kingdoms such as plant kingdom - succulent vegetables, mushrooms and plants, and in animal kingdom - amphibians, etc.

Hydrins I forms the basis of the skin’s acid mantle and Hydrins II forms the basis of moisture-barrier of the skin’s corium layer. Both Hydrins I and II are uniquely involved with the replenishing build-up of new collagen formation ( conversion of procollagen to collagen), maintenance of collagen, maintenance of the optimal healthy skin conditions and skin-healing.

Cross-linked vasotocin ( a neuro peptide ) which is a messenger chemical from the pituitary glands to the skin with instruction to form Hydrins - a small penetrative molecule on contact with dermis and epidermis to replace loss ( aging adults ) or form new Hydrins ( as in young adults ). A spontaneous function of formation/build-up of new collagen 9 as structural links ) takes place when new hydrins are formed.

This thereby results in better skin elasticity and firmness of the skin In-vitro studies have shown neutral salt soluble and/or alkaline soluble collagen fibers and acid soluble collagen may be an intermediate phase in the hydrins based formation/build-up. These formation/build-up contain collagen in its monomeric form (tropocollagen) which structurally consists of three helical polypeptide chains wound round each other to form a coil. In in-vitro assays, Hydrins assisted/formed tropocollagen behaves as a rigid rod with molecular weight of approximately 350,000 a diameter of 14°A and a length of 3,000°A irrespective of its source ( human, animal, or plant ).

Optical rotation, viscosity and ultra-centrifugation studies have demonstrated that Campo Hydrins assisted collagen formation / build-up possess the characteristics of tropocollagen with high viscosity, structural tensile strength and high optical rotation values of human skin collagen, thereby augmenting skin (skin augmentation).

Hydrins - (small penetrative molecules) assisted collagen formation / build-up produces a pronounced and immediate effects when Hydrins included in skin care compositions, leaving the skin feeling smooth and velvety. The Hydrins based replenished collagen build-up is complex triple helix structure gives it high moisture retention properties.
And greatly increased the skin elasticity and firmess.

Hydrins on its own acts to impart lasting moisturization and a silk-smooth feel; and acts to provides protective colloidal structural firmness and as a barrier against water-loss. Campo Hydrins are designed to be replacement of non-functional collagen macromolecules in a topical cosmetic formulation as the collagen are of large structure and do not penetrate the skin to provide any benefits from within the skin in augmenting the skin-firmness.

Hydrins acts as a reservoir, improving elasticity and combating dry flaky skin conditions.

Campo Hydrins are orginally designed and sold exclusively for a major cosmetic brand in Japan (1994) and is the novel mushroom-derived non-animal replacement for Bovine Serum Albumins (B.S.A)
(Comparision secondary screening evaluation assays and in-vitro screening evaluation available on request.)

STRUCTURE

( ( Arg8;Gly 10; ) – Vasotocin ) H-Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Arg – Gly – Gly -Lys – Arg- OH

Campo Hydrins 1 & 2 :
Product Literature | Characteristic | Material Safety Data Sheets |

The information contained herein is accurate to the best knowledge and belief of Campo Research, and specification quoted may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its natural products or their derivatives, since the conditions of use are beyond our control. Statements concerning the possible use are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specifications.

Campo Research accepts no liability whatsoever (except as otherwise provided by law) arising out of the information supplied, the application, adaptation or processing of the products described herein, the use of other materials in lieu of the Campo materials or the use of Campo materials in conjunction with any other products.