Co-Enzyme Q10 and The Skin
Human Bio-Coenzyme Q10 with isoprenoid side chain consist of 10 isoprene units
Currently, CoenzymeQ10 is used for most of the Skin-Whitening cosmetics as it has been reported that the most of these whitening actives are involved in :
"Total and complete inhibition of the amino acid Tyrosine and its formation

An important point should be noted here on Bio-CoEnzyme Q10 - an Essential Biomolecule that is present in all mammalian tissues; and any lackings in the levels of CoEnzyme Q10 presence and manufacture is related with myriads of physiological dysfunctions like the enhanced Aging processes. The formation of CoEnzymes Q10’s quinone ring is synthesized from the Amino Acids Tyrosine and Phenylalanine(map 0130)
Total and complete inhibition of the amino acid Tyrosine and its formation as experienced with most of the presently available Skin Whitening Agents can be implicated in skin Aging and other complications. "
(Balasubramaniam M PhD 1995)
In cosmetic cremes and lotions, Bio-CoenzymeQ10 is an revolutionary anti-aging ingredient that restructures and stimulates the aging skin cells, and acts as a powerful anti-oxidant which tones and smoothen. The Bio-CoEnzyme Q10 maintains skin's energy andnaturally repairs cellular oxygen (radical oxygen) damage as an anti-oxidant.

The most famous introduction in cosmetic products is

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Nivea Visage Anti-Wrinkle Cream Q10, manufactured in Italy (mid way between Bergamo and Milan) and scheduled for launch in USA in October 1998.

Literature References:
Ernster, L. and Daliner, G (1995) Biochemical, Physiological and Medical Aspects of Ubiquinone Function. Biochima et Biophysica Acta, 1271, 195-204.

(More literature references available on request for Skin-whitening Actives related non-postive skin lesions and blotch patches due to loss of CoEnzymes Q10 and related Skin Ceramides)
The following book offers a good general review of CoQ research for the layperson:

  1. E. Bliznakov, Coenzyme Q: The Miracle Nutrient. Bantam Books, NY. 1986.

The following six volume set offers a good review of CoQ research for the cosmetic scientist:
K. Folkers, et al.(eds): Biomedical and Clinical Aspects of Coenzyme Q, Vol 1-6, Elsevier Science Publishers, Amsterdam. 1976 - 1991.


Part1 Part 2 Part3 Dissolution and Relative Bio-availability of Bio-Co-Enzyme Q10 purum