This new development based on cell culture and hydroponics provides a simple, one-step answer to the problem of formulating clear AHA - ceramide systems for advanced skin care.

Ceramide RW is a biologically engineered ceramide complex identical to human skin ceramides, and L-(+)-lactic acid is produced from hydroponically grown tomatoes, where total control over nutrients and root temperatures optimises lactic acid content. The two are brought together to form ALPHA-CERAMIDEIN - your one- step answer to the formulation of advanced skin care systems.

ALPHA CERAMIDEIN^™

• background information

ALPHA HYDROXY ACIDS……….

Facial cosmetics based on sour milk have been used since ancient Egyptian times, a period of some 5000 years. The main active ingredients are believed to be the alpha-hydroxy acids, predominantly lactic acid and its derivatives.

Alpha-hydroxy acids (AHAs) are naturally occurring substances isolated from a variety of sources, such as sour milk, sugar cane, tomatoes and other fruit. They perform a number of functions at the level of the stratum corneum on the skin’s surface.

There are many different kinds of alpha-hydroxy acids, and some out- perform others - even low usage levels. Intensive research has identified lactic acids, particularly the L-form as one of the most effective forms of AHA. Perhaps not surprisingly, this occurs naturally in the body.

Campo’s L-lactic acid is isolated from tomatoes cultivated by hydroponics using root temperature control to optimise yields of L-lactic acid.

……….and CERAMIDES

Ceramide(s) are found in human skin and comprise of 43-46% of the stratum corneum where they play a major role as a water retention barrier. They include sphingosine and fatty acids, and are generally linked with sugars to form structures called glycosphingolipids. Six kinds of ceramides have been identified in the human skin.

Clinical studies of the application of the materials on the forearms of ten healthy male volunteers confirms the augmentation of water-retention, cell to cell adhesion, and in the prevention of barrier changes.

Further clinical studies confirms that human ceramide levels decrease with increasing age, especially on the face, and in one third of individuals studied, on the hands as well.

Campo’s Ceramide RW is a new complex of biologically engineered material, identical to human skin ceramide and is a spin-off from the P34 cdc2 (gene expression) research work on cellular signal transduction, especially in the area of skin cancer proliferation and down-regulation activities of certain natural products; conducted by Kampoyaki Research, Singapore.

AHA + CERAMIDES = ALPHA CERAMIDEIN^™

We have consider the skin as a structure akin to bricks and mortar. The bricks are the stratum corneum cells of the surface skin, and the mortar the intercellular cement that holds the cells together. As skin ages, cells lose their shape, inter-cellular material loosens its grip and the cells slide apart. This gives the skin a slack appearance, it loses its tone and fine lines and wrinkles begin to appear.

Alpha-hydroxy acids work to restore the youthful appearance of the skin. However, they can only complete part of the job. They need the help of ceramides that act like a molecular mortar to reinforce the newer, smaller cells.

Since Elizabeth Arden’s "Alpha-ceramide" 4 steps hit the market in the summer of the 1994, many cosmetic raw material suppliers have been trying to produce a clear, colorless, ceramide liquid based that is soluble in ethanol and water. These efforts have been unsuccessful except for a couple of vegetable ceramide powder types with poor stability. These turn into cloudy opaque liquids from which it is virtually impossible to formulate a clear, colorless, generic to the Arden product.

The answer is Campo^™ Alpha-Ceramidein !!!!!

It has now become possible to super-charge AHA with ceramides, the moisture-enhancing lipids that support and hydrate young skin. Ceramides help to reinforce the skin’s moisture barrier and generally improve the skin’s condition creating a strengthened barrier upon which the AHA complex can work gently and effectively. The L-lactic acid complex works progressively as part of the alpha-ceramides unique step by step system and in this way, all skin types slowly adjust and acclimatise themselves to produce optimal results without the possibility of irritation.

Alpha-ceramidein is a power-packed system to combat fine lines and wrinkles with L-lactic acid isolated from tomatoes and natural alpha-cermides produced by cell culture.

Proposed CFTA name (USA)

CFTA-Proposed Name	:	Alpha-ceramidein L-lactic acid (and) ceramide complex
Color /odour	:	colorless, clear liquid with faint characteristic odour
Application	:	as an additive for emulsion and alcoholic lotions, particularly suggested for addition in W/O and non-ionogenic emulsions.
Application level	:	5 - 8%
Active Ingredients	:	L-lactic acid and ceramide.
Storage	:	Dark and cool in closed containers. Crystals which may form due to long storage or low temperatures have no effect on the quality of the product and can be dissolved by heating and stirring.

ALPHA-CERAMIDEIN was developed and is produced by CAMPO RESEARCH & DEVELOPMENT SYSTEM PTE. LTD. of Singapore.

Alpha-Ceramidein products :
biologicial components | specifications | c o a | microbiological data sheet | material safety data sheet | final report | assay | aha-ceramide complex | science behind alpha-ceremidein |

DISCLAIMER : The information contained herein is accurate to the best knowledge and belief of Campo Research Pte Ltd, and specification quoted may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company,Campo Research Pte Ltd, however, cannot assume any liabilities or risks involved in the use of its natural products or their derivatives or raw materials or ingredients, since the conditions of use are beyond Campo Research Pte Ltd’ s control. Statements concerning the possible use are not intended as recommendations to use our materials in the infringement of any patents or infringements of mandatory regulatory requirements or without any safety evaluations conducted when used in combination with materials of other suppliers.. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specifications. Campo Research Pte Ltd accepts no liabilities of whatsoever either expressed or as other wise arising out of the information supplied, the application, adaptation or processing of the products described herein, or the use of other materials in lieu of the Campo materials or the use of Campo raw materials or ingredients in conjunction with any other products and raw materials. The use of Campo Research Pte Ltd's raw materials or ingredients in any formulations are to be compulsory tested and to be assayed for safety and toxicology profiles evaluations and according the mandatory regulations as required by the laws and regulations of the countries where the evaluation and use of Campo Research Pte Ltd's raw materials or ingredients has been formulated as single components in any carrier systems or as in multi-components formularies. The end-users, marketers; manufacturers, formulation laboratories or importers of Campo Research Pte Ltd' raw materials and ingredients which are incorporated into any formularies as formulated or re-sold or re-exported or assayed in accordance with any mandatory regulatory requirements of any country or infringement of any patents assume all liabilities as that may arise out of the use of Campo Research Pte Ltd's raw materials and ingredients in any formularies in combination with raw materials and ingredients of other suppliers or as single components in any carriers. The definition of users as mentioned in these instances are manufacturers, marketers, formulation laboratories, consultants, and importers assumed all liabilities arising as either personal injuries suits, infringements of patents suits, infrigements of or failures to meet regulatory requirements suits of a formulary either as single components in any carrier systems or in as multi-components formularies in which are may consist of a Campo Research Pte Ltd's raw material or ingredients.